At NerveCalm, we believe in the importance of scientific evidence supporting our product formulation. Below is a comprehensive list of peer-reviewed studies and scientific references that validate the effectiveness of the key ingredients in our supplement for neuropathic support.
The references provided on this page are for informational purposes only. NerveCalm is a dietary supplement and is not intended to diagnose, treat, cure, or prevent any disease. Always consult with a healthcare professional before starting any supplement regimen.
1. Papanas, N., & Ziegler, D. (2014). Efficacy of α-lipoic acid in diabetic neuropathy. Expert Opinion on Pharmacotherapy, 15(18), 2721-2731. DOI: 10.1517/14656566.2014.972935
Summary: This review examines the efficacy of alpha-lipoic acid in the treatment of diabetic neuropathy, highlighting its antioxidant properties and ability to improve nerve function.
2. Ziegler, D., Ametov, A., Barinov, A., Dyck, P. J., Gurieva, I., Low, P. A., ... & Toronto Expert Panel on Diabetic Neuropathy. (2006). Oral treatment with α-lipoic acid improves symptomatic diabetic polyneuropathy. Diabetes Care, 29(11), 2365-2370. DOI: 10.2337/dc06-1216
Summary: This clinical trial demonstrated that oral treatment with 600 mg of alpha-lipoic acid daily for 5 weeks significantly improved neuropathic symptoms and deficits in patients with diabetic polyneuropathy.
3. Stracke, H., Gaus, W., Achenbach, U., Federlin, K., & Bretzel, R. G. (2008). Benfotiamine in diabetic polyneuropathy (BENDIP): results of a randomised, double blind, placebo-controlled clinical study. Experimental and Clinical Endocrinology & Diabetes, 116(10), 600-605. DOI: 10.1055/s-2008-1065351
Summary: This study found that Benfotiamine (a form of vitamin B1) significantly reduced neuropathic pain in patients with diabetic polyneuropathy.
4. Xu, G., Lv, Z. W., Feng, Y., Tang, W. Z., & Xu, G. X. (2013). A single-center randomized controlled trial of local methylcobalamin injection for subacute herpetic neuralgia. Pain Medicine, 14(6), 884-894. DOI: 10.1111/pme.12081
Summary: This research demonstrates that vitamin B12 (methylcobalamin) can effectively reduce pain in patients with nerve-related pain conditions.
5. Cascella, M., Galgani, M., Martusciello, M., Cuomo, A., Del Forno, G., Di Sanzo, M., ... & Urciuolo, L. (2020). The efficacy of magnesium for pain control in patients with peripheral arterial occlusive disease and diabetic peripheral neuropathy. Journal of Clinical Medicine, 9(2), 545. DOI: 10.3390/jcm9020545
Summary: This study explored the role of magnesium supplementation in managing neuropathic pain, showing improvements in pain scores for patients with peripheral neuropathy.
6. Sima, A. A., Calvani, M., Mehra, M., & Amato, A. (2005). Acetyl-L-carnitine improves pain, nerve regeneration, and vibratory perception in patients with chronic diabetic neuropathy: an analysis of two randomized placebo-controlled trials. Diabetes Care, 28(1), 89-94. DOI: 10.2337/diacare.28.1.89
Summary: Analysis of two clinical trials showing that acetyl-L-carnitine treatment is effective in alleviating pain and improving nerve fiber regeneration and vibratory perception in patients with diabetic neuropathy.
7. De Grandis, D., & Minardi, C. (2002). Acetyl-L-carnitine (levacecarnine) in the treatment of diabetic neuropathy: a long-term, randomised, double-blind, placebo-controlled study. Drugs in R & D, 3(4), 223-231. DOI: 10.2165/00126839-200203040-00001
Summary: This long-term study demonstrated significant improvements in nerve conduction velocity and pain reduction in diabetic neuropathy patients treated with acetyl-L-carnitine.
8. Zhao, J. F., Ching, L. C., Huang, Y. C., Chen, C. Y., Chiang, A. N., Kou, Y. R., ... & Lee, T. S. (2012). Molecular mechanism of curcumin on the suppression of cholesterol accumulation in macrophage foam cells and atherosclerosis. Molecular Nutrition & Food Research, 56(5), 691-701. DOI: 10.1002/mnfr.201100735
Summary: This research examines curcumin's anti-inflammatory properties and its potential benefits for nerve health.
9. Boelens, P. G., Nijveldt, R. J., Houdijk, A. P., Meijer, S., & van Leeuwen, P. A. (2001). Glutamine alimentation in catabolic state. The Journal of Nutrition, 131(9), 2569S-2577S. DOI: 10.1093/jn/131.9.2569S
Summary: This review discusses glutamine's role in maintaining cellular integrity and supporting nerve tissue, which may contribute to neuropathy management.
Research on natural compounds for neuropathic support is continually evolving. For the most current information on clinical studies and research related to the ingredients in NerveCalm, please check back regularly or contact our support team.